The Vitamin D Regimen – Vitamin D Anti Inflammatory Regimen for Cluster Headache

High-Dose Vitamin D3 Therapy in Psoriasis: Reassuring Data

Craig Stewart — Sun, 09 Nov 2025 06:45:28 +0000

Study Overview

This retrospective study evaluated 95 adults with chronic forms of psoriasis treated for up to twelve months using individualised daily doses of vitamin D3 ranging from 30,000 to 60,000 IU per day. All participants discontinued immunosuppressants, corticosteroids, biologics, and phototherapy during the study period, allowing for an isolated assessment of vitamin D3’s effects.

At baseline, 65 percent of patients were vitamin D deficient, with serum 25-hydroxyvitamin D 25(OH)D levels below 30 ng/mL. Within this group, almost 40 percent had levels under 20 ng/mL, representing severe deficiency.

Dosing was stratified by body weight: 30,000 IU per day for individuals between 60 and 75 kg and 40,000 IU per day for those above 75 kg. For patients with 25(OH)D below 20 ng/mL, a loading dose of 600,000 IU administered over ten days (60,000 IU per day) was used before transitioning to daily dosing in close similarity to the 600,000 IU loading dose used for episodic CH upon commencement of the anti-inflammatory regimen. Those with levels between 20 and 29 ng/mL received a 300,000 IU load across five days. Importantly, dosing was adjusted according to parathyroid hormone (PTH) suppression and ionised calcium values rather than 25(OH)D levels alone, a protocol designed to correct vitamin D resistance frequently observed in autoimmune conditions and a foundational premise of the Coimbra protocol.

Clinical Findings

After twelve months, mean PASI (Psoriasis Area and Severity Index) scores improved from 17.83 to 6.52, with 77 percent of participants achieving at least a 50 percent reduction and over 50 percent surpassing 75 percent improvement. Serum 25(OH)D concentrations rose above 100 ng/mL across the cohort, while PTH levels fell from a mean of 52.5 pg/mL to 32.5 pg/mL.

Ionised calcium remained within normal limits throughout, and no cases of hypercalcemia, renal dysfunction or vitamin D toxicity were observed, even in patients receiving up to 60,000 IU per day for several months. This outcome strongly reinforces that when therapy is guided by calcium and PTH monitoring, vitamin D3 can be administered safely at doses far above conventional recommendations.

Why This Matters to Cluster Headache Patients

For cluster headache sufferers using or exploring the Vitamin D3 Anti-Inflammatory Regimen, this study carries particular relevance. The loading protocol in Mahtani’s cohort, 600,000 IU over ten days for patients below 20 ng/mL, is nearly identical to the 600,000 IU loading schedule used in the cluster headache protocol for episodic CH.

However, the key difference lies in maintenance dosing. While the standard CH regimen typically prescribes 10,000 IU per day (or 50,000 IU per week), Mahtani’s patients required 25,000 to 45,000 IU per day on average, with some maintained at 50,000 IU per day for several months before tapering.

For CH patients, this context is highly reassuring. Doses between 10,000 and 20,000 IU per day, often perceived as “high,” are, in reality, modest compared to doses safely employed in other inflammatory diseases such as the Coimbra and LGS protocol. In the psoriasis cohort, even substantially higher doses produced no renal impairment when guided by PTH and calcium monitoring.

Reassessing “High” Doses

In the CH community, many patients are initially anxious about taking 10,000 IU per day, fearing it exceeds safe limits. Yet the Mahtani data make clear that 10,000 IU per day is at the lower end of an established therapeutic range for chronic inflammatory conditions. Even doses four to five times higher have been administered safely under appropriate laboratory oversight. For those with refractory CH who require escalation beyond 10,000 IU per day to achieve PTH suppression and sustained remission, this study provides strong, independent clinical evidence that such dosing can be physiologically tolerated long term.

Conclusion

Mahtani’s 2025 study represents a significant contribution to the broader understanding of vitamin D3’s therapeutic potential. It demonstrates that high-dose daily supplementation, when tailored by individual responsiveness rather than arbitrary limits, can be both effective and safe in chronic immune-mediated disease. For CH patients following the Vitamin D3 Anti-Inflammatory Regimen, it offers an additional layer of reassurance. Both the loading and maintenance strategies align closely with those used in psoriasis but at generally lower doses.

Rather than viewing 10,000 IU per day as excessive, regimen users can take confidence that this amount sits well within a physiologically validated range, and that even higher titrations, if needed for complete CH remission, are safe when done under medical supervision with the appropriate monitoring of labs.

Mahtani R., Singh S., Nair P. M., Singh S. P., Goyal M. (2025). Prolonged high dose daily oral vitamin D3 in the management of psoriasis: A retrospective chart analysis. IP Indian Journal of Clinical and Experimental Dermatology, 11(3), 288-296. https://doi.org/10.18231/j.ijced.89447.1758864688

The Supplements I Use for the Vitamin D3 Anti-Inflammatory Regimen for Cluster Headache

Craig Stewart — Mon, 02 Jun 2025 18:31:21 +0000

People often ask what supplements I use for the Vitamin D3 Anti-Inflammatory Regimen to control my cluster headache. I’m based in New Zealand, and if you’re reading this from overseas, these specific products may not be available in your country. The links below are not affiliate links. They’re simply included to help others who may not have local access or are unsure what to purchase.

This list reflects what I’ve used or currently use. Other CH warriors likely use different brands. Pete, the chronic CH patient who pioneered the regimen, uses different brands too. We live in different countries. This is just to say that you may need to adapt based on what’s available to you, or your preferences for quality, budget, or formulation. This list should provide a decent enough guide to point you in the right direction.

Many people struggle to find a multivitamin that includes the calcium, zinc, boron and retinol. If one of the items is missing, you may do fine without or source that particular item as a standalone supplement.

Important Notes Before You Begin

Always test your vitamin D levels before starting, and monitor regularly. The target 25(OH)D level for this protocol is typically 80 to 100 ng/mL (200 to 250 nmol/L).

Always consult with a physician before starting this or any high-dose supplementation regimen. The loading phase begins with a single 10,000 IU dose of vitamin D3 to ensure no adverse reaction.

For full instructions, safety information, and detailed dosing protocols, download the reference guide available at vitamindregimen.com

Supplement List and Where to Buy

400 mg Magnesium Glycinate (2 capsules per day)
Nobi Nutrition Magnesium Glycinate (120 capsules)

Multivitamin

Men’s Formula
Nature Made Multi For Him (90 tablets)

Women’s Formula
Nature Made Multi For Her (90 tablets)

Vitamin K2

MK-4 1,000 mcg and MK-7 100 mcg
Life Extension Super K (90 softgels)

Methylated B-Complex

B-50 Complex
Solaray Methyl B-Complex 50 (60 capsules)

Final Reminders

Many people live in countries where all of these supplements are available over the counter, including high-dose vitamin D3. These links are helpful for those who are unable to obtain the required dosages locally or who face restrictions in accessing specific components.

Because delays in shipping are possible, it’s important to have effective cluster headache abortive therapies available during the waiting period and loading phase. High-flow oxygen remains the gold standard. I personally abort attacks within six minutes using the top-rated Cluster O2 Kit and the correct breathing technique. Prednisone may be considered as a bridging option if needed.

Always consult with your physician before starting the regimen. Ensure that baseline lab tests are completed and that your doctor has reviewed the protocol against any existing health conditions or medications that may contraindicate or preclude vitamin D therapy.

Get Started

To learn more, download the full guide and access further resources at
vitamindregimen.com

If you’re suffering and searching for answers, this protocol might be worth exploring. Start with the guide, take it to your doctor, and take it step by step.

How to Stop a Cluster Headache Cycle: Exploring Traditional and Natural Approaches

Craig Stewart — Sat, 30 Nov 2024 22:45:41 +0000

Understanding the Cluster Headache Cycle

A cluster headache cycle refers to the period when attacks occur frequently, often daily or multiple times per day over several weeks or even months. These cycles are typically followed by remission periods with no headaches. While the exact cause of cluster headaches isn’t fully understood, treatments aim to reduce attack frequency, severity, and duration while preventing future cycles.

Traditional Approaches to Stopping a Cluster Cycle

Prednisone (Corticosteroids)

Prednisone is often used as a first-line treatment to interrupt a cluster headache cycle. It works by suppressing inflammation. A short-term, high-dose taper of prednisone can stop attacks for many sufferers, but prolonged use is avoided due to potential side effects such as weight gain, insomnia, and bone thinning.

Verapamil (Calcium Channel Blocker)

Verapamil is one of the most commonly prescribed preventive medications for cluster headaches. Patients often start with low doses, which are gradually increased. Regular monitoring is required to avoid side effects like low blood pressure and heart rhythm issues.

Monoclonal Antibodies (CGRP Inhibitors)

Newer treatments like monoclonal antibodies (mAbs) target calcitonin gene-related peptide (CGRP), a molecule involved in pain signalling and inflammation. These injections are typically designed to be used monthly as a preventative treatment for cluster.

Oxygen Therapy

High-flow oxygen therapy is a highly effective acute treatment for aborting individual attacks. Breathing pure oxygen via a non-rebreather mask at a minimum flow rate of 10-15 lpm can quickly stop a headache but unfortunately doesn’t prevent future attacks in a cycle.

Breaking or Preventing a Cycle Naturally: The Vitamin D3 Anti-Inflammatory Regimen

For those looking for a preventive more natural approach, the Vitamin D3 Anti-Inflammatory Regimen is a promising option to consider. This regimen aims to reduce systemic inflammation, which may play a role in cluster headache cycles by optimizing Vitamin D3 levels and incorporating key cofactors like magnesium, omega-3 fatty acids, zinc, boron and vitamin K.

Many patients report a significant reduction in cluster headache frequency, severity, or even complete remission from attacks after following the Vitamin D regimen. By addressing potential inflammatory and immune dysfunction at the root, this natural approach works to break or prevent cycles without the side effects of conventional medications.

Which Approach Is Right for You?

Breaking a cluster headache cycle often requires a combination of strategies tailored to the individual. Prednisone, verapamil, and newer mAbs can provide immediate or preventive relief, but they may come with side effects or require careful monitoring.

The Vitamin D3 Anti-Inflammatory Regimen presents as a natural, long-term solution by targeting the underlying inflammation that may trigger cluster cycles. It can be used alongside traditional treatments or as a standalone preventive measure under the care and guidance of your primary care physician.

In Conclusion

Stopping a cluster headache cycle is possible with the right approach. Whether you choose conventional treatments like prednisone and verapamil or explore natural options like the Vitamin D3 regimen, it’s important to find a plan that works for you.

If you’re struggling with cluster headaches, know that there are safe, effective options available to help you manage your condition.

To learn more about the Vitamin D Anti-Inflammatory Regimen, visit The Vitamin D Regimen and download the primary care physicians full reference guide or watch the interview with Pete Batcheller.

With a stroke of luck and a bit of guidance from your primary care physician, the Vitamin D3 Anti-Inflammatory Regimen for Cluster Headache may be the treatment option you’ve been looking for that not only provides relief from cluster headache but also provides additional health benefits without the side effects of traditional medications used to treat cluster headache.

Disclaimer

The information provided here is for educational purposes only and is not intended as medical advice. Always consult with your doctor or healthcare provider before starting any new supplement or treatment regimen, particularly if you have pre-existing medical conditions, are pregnant, breastfeeding, or are taking medications. Your healthcare provider will be able to assess your individual needs, recommend appropriate dosages, and monitor your response to supplements. Never disregard professional medical advice or delay seeking it because of something you have read here.

Are Cluster Headaches Life-Threatening?

Craig Stewart — Sat, 30 Nov 2024 21:29:09 +0000

From a medical standpoint, cluster headaches themselves are not considered life-threatening. They do not cause brain damage, stroke, or other direct physical harm. However, the condition is not without serious risks, especially when viewed through the lens of its broader impact on mental and emotional health.

Mental Health Risks

The nickname “suicide headaches” stems from the significant psychological toll this condition can take. The relentless pain, coupled with its cyclical nature, often leads to feelings of hopelessness, anxiety, and depression. Without proper support, these emotional challenges can escalate, increasing the risk of suicidal thoughts or behaviors, in fact cluster headache sufferers are 20 times more likely to take their own life.

Medication Risks

The severity of cluster headaches drives many sufferers to rely heavily on medications such as triptans or painkillers. Overuse of these treatments can lead to rebound headaches, dependency, or harmful side effects, complicating the management of the condition.

Safety Risks During Attacks

The sudden onset and debilitating nature of cluster headaches can make certain activities, like driving or operating machinery, dangerous. Additionally, nocturnal attacks often disrupt sleep, leading to chronic fatigue, which can further impair daily functioning.

Quality of Life Impacts

The recurring pain, coupled with the fear of the next attack, can lead to social withdrawal, strained relationships, and challenges at work. This erosion of day-to-day life can feel insurmountable for many sufferers.

Why Effective Management Is Crucial

Although cluster headaches are not fatal, the risks associated with their impact on mental health, safety, and overall quality of life make effective management essential. The right approach can help minimize these risks and improve day-to-day functioning.

Conventional Treatments

Acute Treatments: High-flow oxygen therapy and injectable or nasal triptans can quickly abort an attack.

Preventive Medications: Drugs like verapamil, corticosteroids, and lithium are commonly prescribed to reduce attack frequency and intensity during active periods.

Neuromodulation: Devices like vagus nerve stimulators are emerging as options for managing severe cases.

The Role of Chronic Inflammation in Cluster Headaches

Emerging research points to a link between cluster headaches and systemic inflammation. Chronic low-grade inflammation may contribute to the over-activation of the hypothalamus and the trigeminal nerve, both considered key players in the development of cluster headaches. Addressing this inflammation at its source offers a promising pathway for managing the condition.

A Natural, Holistic Approach: The Vitamin D Anti-Inflammatory Regimen

One innovative approach that has gained attention among sufferers and researchers alike is the Vitamin D3 Anti-Inflammatory Regimen. This protocol focuses on reducing inflammation and supporting the body’s immune system through optimal levels of Vitamin D3, combined with key cofactors such as magnesium, omega-3 fatty acids, and vitamin K2.

How It Works

Whilst there is little evidence in published medical journals supporting the use of Vitamin D3 for the treatment of cluster headache, the designer of the regimen and fellow chronic cluster headache sufferer, Pete Batcheller, suggests that Vitamin D3 helps regulate the immune system, reducing the release of pro-inflammatory cytokines that may contribute to cluster headaches.

Many individuals following the regimen have reported significant improvements, including fewer attacks, reduced severity, or complete remission from cluster headache. This natural, non-invasive approach addresses the potential contributing factors that pave the way for the presentation of cluster headaches, offering a long-term solution that complements conventional treatments.

In Conclusion

While cluster headaches are not directly life-threatening, their profound impact on mental health, daily life, and overall well-being can feel dangerous in their own way. Proper management is critical, not just for reducing the frequency and severity of attacks but for reclaiming your quality of life.

If you’re struggling with cluster headaches, know that there are safe, effective options available to help you manage your condition.

To learn more about the Vitamin D Anti-Inflammatory Regimen, visit The Vitamin D Regimen and download the primary care physicians full reference guide or watch the interview with Pete Batcheller.

Disclaimer

Full Monty Supplements

Craig Stewart — Sun, 22 Sep 2024 18:33:23 +0000

Introduction to the Full Monty

The Antihistamine Full Monty is a powerful supplement protocol designed to address the immune system’s reaction to allergens, which can exacerbate cluster headaches (CH) and migraines. This approach complements the Vitamin D Anti-Inflammatory Regimen by targeting histamine release—a common trigger for headaches. Histamine, produced in response to allergens or infections, can inflame nerves and brain tissues, making CH and migraine episodes more frequent and intense. The Full Monty provides a natural alternative to traditional antihistamines like Benadryl, offering benefits without the drowsiness or long-term side effects associated with those medications.

The Full Monty protocol is particularly useful for individuals who experience little improvement after completing the initial five days of Vitamin D3 loading or those whose headaches return after a period of remission. It can also be started simultaneously with the Vitamin D regimen for migraine sufferers. This protocol works by upregulating the expression of the Vitamin D Receptor (VDR) and supporting immune health with potent antioxidants and anti-inflammatory agents.

Key supplements in the Full Monty include Turmeric (Curcumin), Quercetin, and Vitamin C—all recognized for their ability to combat histamine-induced inflammation. These natural compounds not only reduce histamine levels but also support the body’s immune response by acting as antioxidants, antiviral, and antibacterial agents. For those experiencing chronic headaches, these supplements help manage inflammation and improve the body’s ability to process Vitamin D effectively.

The Full Monty protocol recommends starting with high doses of these supplements (1-2 grams per day of Turmeric, Quercetin, and Vitamin C) and then tapering to lower maintenance doses. For added support, Omega-3 fatty acids, N-Acetyl Cysteine (NAC), Selenium, Zinc, and Melatonin can be introduced depending on individual needs and responses. Together, these supplements work to maintain a stable, headache-free state by mitigating allergic reactions and restoring the balance of inflammatory and anti-inflammatory signals in the body.

Links

People often message me asking what supplements to buy and where to get the items for the full monty. Here is a list below of the supplements along with iHerb links. This is not to offer brand recommendations, buy whatever brand of supplement that you like.

Primary Antihistamine Supplements

A. 1 to 2 Grams/day Turmeric (Curcumin) with Piperine

https://www.iherb.com/pr/nature-s-bounty-turmeric-plus-black-pepper-extract-1-000-mg-60-capsules/86136

B. 1 to 2 Grams/day Quercetin

https://www.iherb.com/pr/kal-quercetin-1-000-mg-60-tablets/106633

C. 1 to 2 Grams/day Resveratrol

https://www.iherb.com/pr/lake-avenue-nutrition-resveratrol-complex-500-mg-250-veggie-capsules/96289

D. 8 Grams/day vitamin C

https://www.iherb.com/pr/california-gold-nutrition-buffered-gold-c-non-acidic-vitamin-c-powder-sodium-ascorbate-8-40-oz-238-g/82704

Optional As Needed

E. 2 Grams/day Omega-3 Fish Oil (EPA and DHA)

F. 250 mcg/day Selenium